Compendium Model of AkT for Cell Survival/Death and its Equivalent Bio-Circuit
Shruti Jain,1 Pradeep K. Naik2, Sunil V. Bhooshan3
1Shruti Jain, Electronics and Communication, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, India.
2Pradeep K. Naik, Department of Biotechnoligy and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, India.
3Sunil V. Bhooshan, Electronics and Communication, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, India).
Manuscript received on July 01, 2012. | Revised Manuscript received on July 04, 2012. | Manuscript published on July 05, 2012. | PP: 91-97 | Volume-2, Issue-3, July 2012. | Retrieval Number: C0703052312 /2012©BEIESP
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© The Authors. Published By: Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: This paper demonstrates the compendium model of AkT (protein kinase B) for cell survival/ death. AkT is a central signaling molecule in the Tumor Necrosis factor-α (TNF), Epidermal Necrosis Factor (EGF) and Insulin pathway. Model demonstrates how AkT promotes cell survival by inactivating several targets, including forkhead transcription factors, p53, GSK-3B and caspase-9 and activating Bad, NF-κB and mTOR. On the basis of model for AkT we have made the truth tables, Boolean equations and then implement the equations using logic circuits and Bio-circuits showing cell survival and death. Heat map of 13 time points at 0, 5, 15, 30, 60, and 90 min and 2, 4, 8, 12, 16, 20, and 24 hr for ten cytokine treatments of TNF, EGF and Insulin has been taken for AkT signal. We have plotted their corresponding graph of time-dependent signals. The results obtain will give information on how the input signals inducing cell survival/ death should be modulated to achieve desire outputs
Keywords: AkT, Pro-Apoptotic, Anti-Apoptotic